A look at the professional and personal lives of the staff at New York's Knickerbocker Hospital during the early part of the twentieth century. Every day they must deal with lack of funding, personal conflicts, egotism, racial tensions, personal vices, drug addiction, affairs, closed minds, dated nigh-medieval medical techniques and them and their experimental new techniques being misunderstood by most, in order to keep the hospital going and give the ill the help they need. The pressure is enormous and leaves its mark on the souls of most of them.

This terrifying thriller follows widow Lisey Landon as a series of disturbing events revives memories of her marriage to author Scott Landon and the darkness that plagued him.